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Oxycodone is an opioid analgesic prescribed for moderate to severe pain when other treatments are not sufficient. It works by binding to opioid receptors in the brain and spinal cord to reduce the sensation of pain. Dosage is individualized based on pain severity, prior opioid exposure, and patient response. For opioid-naïve adults, clinicians often start with 5–10 mg of immediate-release oxycodone every 4–6 hours as needed, adjusting cautiously. Extended-release formulations are taken on a fixed schedule and must be swallowed whole—never crushed, chewed, or split—to prevent overdose. Oxycodone should be taken exactly as prescribed, with regular monitoring for side effects such as drowsiness, constipation, nausea, or slowed breathing. Alcohol and other sedatives increase risk and should be avoided. Because of dependence and overdose potential, the lowest effective dose for the shortest duration is recommended, with gradual tapering when discontinuing.