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Oxycodone is an opioid pain medication prescribed for moderate to severe pain when non-opioid options are inadequate. It reduces pain by acting on opioid receptors in the central nervous system. Dosage is individualized based on pain intensity, prior opioid exposure, and patient response. For opioid-naïve adults, clinicians may initiate 5–10 mg of immediate-release oxycodone every 4–6 hours as needed, with careful titration. Extended-release formulations are taken on a fixed schedule and must be swallowed whole—never crushed or chewed—to avoid overdose. Oxycodone should be taken exactly as prescribed, and patients require regular monitoring for effectiveness and side effects such as drowsiness, constipation, nausea, or slowed breathing. Alcohol and other sedatives should be avoided. Due to risks of dependence and overdose, therapy typically uses the lowest effective dose for the shortest duration, with gradual tapering when discontinuing.