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Oxycodone is an opioid analgesic prescribed for the management of moderate to severe pain when other treatments are insufficient. It works by binding to opioid receptors in the brain and spinal cord to reduce the perception of pain. Dosage is individualized based on pain severity, prior opioid exposure, and patient response. For opioid-naïve adults, clinicians may start with 5–10 mg of immediate-release oxycodone every 4–6 hours as needed, adjusting cautiously. Extended-release formulations are taken on a fixed schedule and should never be crushed or chewed. Oxycodone should be taken exactly as prescribed, and patients should be monitored regularly for effectiveness and side effects such as drowsiness, constipation, nausea, or slowed breathing. Alcohol and other sedatives increase risk and should be avoided. Because of dependence and overdose risk, the lowest effective dose for the shortest duration is recommended, and discontinuation should be done gradually under medical guidance.