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About the Walk-A-Thon

This is our 20th annual Walk-A-Thon! Join us as a fundraiser, donor, or share this page with others to help make this year's event the best one yet!


About Gifts in Bloom

Since 1985, our Foundation has been all about the children and the smiles they put on everyone's faces. We support multiple causes during the year including our annual gala, golf event, and Walk-A-Thon. For additional questions please make sure to visit our website or reach out on social media.


 

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Tapentadol is a prescription opioid analgesic used to treat moderate to severe pain. It is designed to work through two mechanisms, providing both opioid-based pain relief and additional pain-modulating effects. It is often prescribed when other pain medications do not provide sufficient relief or cannot be tolerated.

Tapentadol is available in immediate-release (for acute pain) and extended-release (for chronic pain) formulations.

How Tapentadol Works

Tapentadol has a dual mechanism of action:

  1. Mu-opioid receptor agonism — reduces pain signaling in the brain and spinal cord.

  2. Norepinephrine reuptake inhibition (NRI) — enhances the body’s ability to suppress pain signals.

This combination can provide effective relief with potentially fewer gastrointestinal side effects than some other opioids.

Common Medical Uses

Tapentadol may be prescribed for:

  • Moderate to severe acute pain (post-surgery, injury)

  • Chronic musculoskeletal pain such as osteoarthritis

  • Neuropathic pain associated with diabetic neuropathy (extended-release formulations)

Possible Side Effects

Some people may experience:

  • Nausea or vomiting

  • Dizziness or drowsiness

  • Constipation

  • Headache

  • Dry mouth

  • Fatigue

More serious effects may occur with high doses or drug interactions.

Safety Considerations

  • Tapentadol is an opioid, so it carries risks of dependence, tolerance, and withdrawal.

  • It must not be combined with alcohol, benzodiazepines, sleep medications, or other opioids due to the risk of dangerous breathing suppression.

  • Using it with MAO inhibitors or certain antidepressants may increase the risk of serotonin syndrome.

  • Individuals with breathing disorders, liver disease, or a history of substance misuse require careful medical supervision.

  • Never adjust the dose without consulting a healthcare provider.

When to Seek Emergency Help

Seek urgent medical attention if you notice:

  • Slow or difficult breathing

  • Extreme drowsiness or inability to stay awake

  • Confusion or unusual behavior

  • Allergic reactions (rash, swelling, difficulty breathing)

  • Signs of overdose

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